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Updated: Apr 29, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
The future of pharmacotherapy for obsessive-compulsive disorder may lie in a better understanding of its
1The University of Sydney, Nepean Hospital, Sydney Medical School, Discipline of Psychiatry , PO Box 63, Sydney/Penrith, New South Wales 2751 , Australia +61 2 4734 2585 ; +61 2 4734 3343 ; vbrakoulias@bigpond.com , vlasios.brakoulias@sydney.edu.au.
Abstract:
Pharmacological treatments currently available to treat obsessive-compulsive disorder (OCD) rarely produce remission. This Editorial aims to encourage more targeted research based on the specific OCD symptoms patients primarily present with. Specific OCD symptoms have been associated with distinct clinical characteristics, aetiological hypotheses and treatment responses. Treatment studies should use these findings to develop more targeted pharmacotherapy for patients with OCD.
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