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Updated: Apr 29, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
Differential expression of stromal aromatase in obese females is regulated by DNA methylation
Xian-Cheng Zeng1, Xiang Ao2, Hai-Feng Yang3
1Department of General Surgery, Zengcheng People's Hospital (Boji-Affiliated Hospital of Sun Yat-Sen University), Zengcheng 511300, P.R. China.
Abstract:
Obesity increases the incidence, progression and mortality of breast cancer among postmenopausal females. This is partly due to excessive estrogen production in the adipose tissue of obese females. Aromatase is a key enzyme in estrogen biosynthesis. In the current study, the tensional force‑triggered inducibility of aromatase expression was observed to vary in ASCs isolated from different disease‑free individuals. In addition, this phenomenon was associated with the activation of the aromatase PII promoter and its DNA methylation load. These findings highlight the impact of tensional forces on estrogen biosynthesis in obese females.
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