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Related Concept Videos

Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

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Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

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Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
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Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
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Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

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The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
40
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

26
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
26

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The postprandial situation as a pro-inflammatory condition.

Marijke A de Vries1, Boudewijn Klop1, Silvia A Eskes1

  • 1Department of Internal Medicine, Centre for Diabetes and Vascular Medicine, Sint Franciscus Gasthuis, Rotterdam, The Netherlands.

Clinica E Investigacion En Arteriosclerosis : Publicacion Oficial De La Sociedad Espanola De Arteriosclerosis
|May 29, 2014
PubMed
Summary
This summary is machine-generated.

Postprandial lipemia, linked to cardiovascular disease, involves remnant lipoproteins causing inflammation. Interventions like diet and exercise can reduce this inflammation, potentially lowering atherosclerosis risk.

Keywords:
Apolipoprotein B48Apolipoproteína B48AteroesclerosisAtherosclerosisChylomicronQuilomicrónTriglicéridosTriglyceride

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Area of Science:

  • Cardiovascular Science
  • Inflammation Biology
  • Nutritional Science

Background:

  • Postprandial lipemia is a risk factor for cardiovascular disease.
  • Remnant lipoproteins contribute to the inflammatory process in atherosclerosis.
  • This process involves leukocyte and endothelial cell activation, leading to monocyte migration and foam cell formation.

Purpose of the Study:

  • To review the current understanding of postprandial inflammation in atherosclerosis.
  • To explore potential interventions for reducing postprandial inflammation.

Main Methods:

  • Literature review of current pathophysiological concepts.
  • Analysis of emerging evidence on lifestyle and pharmaceutical interventions.

Main Results:

  • Postprandial inflammation is driven by remnant lipoproteins, leukocyte activation, and monocyte migration.
  • Dietary interventions (polyphenols, virgin olive oil, carotenoids) and exercise show potential in reducing inflammation.
  • Pharmaceuticals like fibrates and statins also mitigate postprandial inflammation.

Conclusions:

  • Postprandial inflammation plays a significant role in atherosclerosis development.
  • Lifestyle modifications and certain medications can effectively reduce postprandial inflammation, offering therapeutic potential.