Related Experiment Video

Updated: Apr 29, 2026

Multiphoton Intravital Imaging for Monitoring Leukocyte Recruitment during Arteriogenesis in a Murine Hindlimb Model
07:50

Multiphoton Intravital Imaging for Monitoring Leukocyte Recruitment during Arteriogenesis in a Murine Hindlimb Model

Published on: September 30, 2021

1.6K

FLAIR vascular hyperintensities and dynamic 4D angiograms for the estimation of collateral blood flow in posterior

Alex Förster1, Holger Wenz, Hans Ulrich Kerl

  • 1Department of Neuroradiology, Universitätsmedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany, Alex.Foerster@umm.de.

Neuroradiology
|May 29, 2014
PubMed
Abstract

Insights

Assessing collateral blood flow in posterior circulation occlusion using MRI reveals that while FLAIR vascular hyperintensities (FVH) are common, dynamic 4D angiograms combined with FVH offer better prognostic value for ischemic lesion size.

Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Posterior circulation occlusion presents challenges in assessing collateral blood flow.
  • MRI-based approaches, including FLAIR vascular hyperintensities (FVH) and dynamic 4D angiograms, are utilized to evaluate collateral circulation.
  • Understanding collateral flow is crucial for predicting ischemic lesion outcomes.

Purpose of the Study:

  • To assess collateral blood flow in posterior circulation occlusion using MRI-based methods.
  • To investigate the relationship between collateral flow indicators (FVH, 4D angiograms) and ischemic lesion size and growth.
  • To determine the prognostic value of these MRI findings.

Main Methods:

  • Retrospective analysis of MRI findings in 28 patients with posterior cerebral artery (PCA) occlusion and 10 with basilar artery (BA) occlusion.
  • Emphasis on evaluating distal FVH and collateralization using dynamic 4D angiograms.
  • Correlation analysis between MRI findings and diffusion-weighted imaging (DWI) and DWI-perfusion-weighted imaging (PWI) metrics.

Main Results:

  • Distal FVH was observed in 62.1% of PCA and 80% of BA occlusion cases.
  • Collateralization on dynamic 4D angiograms showed varying grades across patients.
  • FVH grade did not correlate with lesion size or DWI-PWI mismatch; however, 4D angiogram collateralization correlated inversely with initial lesion size and moderately with mismatch. The combination of FVH and 4D angiogram collateralization showed strong inverse correlation with lesion size and high correlation with mismatch.

Conclusions:

  • FLAIR vascular hyperintensities (FVH) are frequent in posterior circulation occlusions but have limited prognostic value.
  • Dynamic 4D angiograms are effective for grading collateral blood flow.
  • Combining FVH and 4D angiogram assessments improves characterization of collateral flow and may have prognostic relevance.

More Related Videos

Non-invasive Assessment of Microvascular and Endothelial Function05:41

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

15.8K
Time-Resolved, Dynamic Computed Tomography Angiography for Characterization of Aortic Endoleaks and Treatment Guidance via 2D-3D Fusion-Imaging09:32

Time-Resolved, Dynamic Computed Tomography Angiography for Characterization of Aortic Endoleaks and Treatment Guidance via 2D-3D Fusion-Imaging

Published on: December 9, 2021

2.6K

Related Concept Videos

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
467
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
557
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
762