[Experimental study on the wound healing after tongue resection produced VX2 carcinoma]

In order to macroscopically and pathohistologically study the healing process of vulnerary regions after resection of transplanted tumors, we transplanted VX2 carcinoma into the tongue of rabbits and conducted partial resection of the tongue which had taken the carcinoma in the early stage. The results obtained were as follows: 1. Partial resection of the tongue was performed in the control group and in the transplanted group. The comparative observation was conducted macroscopically and pathohistologically in terms of the healing condition at days 3, 5, 7, 14, and 28 after the surgery. 2. Macroscopically, findings up to day 7 in the transplanted group revealed slightly stronger changes with respect to vulnerary fossae, edema-like swelling ruber than those in the control group and slight changes at 14 and then later. 3. Pathohistologically, the transplanted group showed delayed regeneration of vulnerary mucopithelium, strong inflammatory cellular infiltration, strong atrophy and disappearance of myofieber, and irregular running of myofiber bundle. Improvement was recognized at day 14 and later and the difference in tissue restoration between the two group was slight. The results confirmed that the healing process of the vulnerary region in cases of partial resection of the tongue transplanted tumor was slightly delayed even in carcinoma at an early stage, and quite term effects remained.