[Experimental chemotherapy using transplantable human oral cancer in nude mice by SRC assay]

I studied fundamentally 6-days subrenal capsule assay, using human oral cancer transplanted in nude mice. The relative variation of tumor size (delta TS/TSO) was calculated as follows; delta TS/TSO = (TS6-TSO)/TSO X 100(%), where TS 6 was the tumor size on day 6 and TSO that on day O, and more than a 10% decrease of delta TS/TSO in the treated group was considered as positive for chemosensitivity. The chemosensitive rates were 38.0 +/- 8.1% (mean +/- standard deviation) for control, -8.0 +/- 8.5% for 5-FU, 1.8 +/- 16.7 for PEP, 5.0 +/- 9.1% for CDDP, -26 +/- 9.6% for 5-FU + PEP and -17.0 +/- 6.7% for 5-FU + CDDP. A single chemotherapy was negative, but combination chemotherapy was positive and few side effects (body weight loss) was showed. The 6-days SRC assay (combined anticancer drugs) appeared to be useful for selecting sensitive drugs for oral cancer patient.