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Updated: Apr 29, 2026
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Predictive Immune Modeling of Solid Tumors
Published on: February 25, 2020
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Primer on immuno-oncology and immune response
Rajni Kannan1, Kathleen Madden1, Stephanie Andrews2
1Laura and Isaac Perlmutter Cancer Center, New York University Medical Center in New York City.
Clinical Journal of Oncology Nursing
|May 29, 2014
Summary
Immuno-oncology uses agents like sipuleucel-T and ipilimumab to boost antitumor immunity, improving long-term survival. These therapies may cause immune-related side effects requiring careful monitoring and management.
Area of Science:
- Oncology
- Immunology
Background:
- Tumor immunogenicity understanding fuels immuno-oncology.
- Cancer evades immune system via regulatory circuits.
Purpose of the Study:
- Introduce novel immunomodulatory agents for malignancy.
- Highlight sipuleucel-T and ipilimumab in cancer treatment.
Main Methods:
- Focus on immunotherapies stimulating endogenous antitumor responses.
- Contrast immunotherapy with cytotoxic chemotherapy.
Main Results:
- Sipuleucel-T and ipilimumab show significant long-term survival improvements.
- Adverse events manifest as low-grade immune-related inflammatory conditions.
Conclusions:
- Management guidelines emphasize early recognition and corticosteroid treatment for immune-related adverse events.
- Continued patient follow-up by healthcare providers is crucial post-therapy.
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