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Risk factors of hyperthyroidism with hepatic function injury: a 4-year retrospective study
1Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, China.
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|May 29, 2014
Summary
Graves' disease can cause liver injury, with risk factors including older age, longer disease duration, and higher thyroid hormone levels. Radioactive iodine therapy is identified as the optimal treatment choice for these patients.
Area of Science:
- Endocrinology
- Hepatology
- Nuclear Medicine
Background:
- Hepatic function injury is a common complication of hyperthyroidism, particularly Graves' disease (GD).
- This complication impacts treatment selection and efficacy.
- Understanding clinical and biochemical patterns is crucial for managing GD patients with liver injury.
Purpose of the Study:
- To describe clinical and biochemical patterns in Graves' disease patients experiencing hepatic function injury.
- To identify factors influencing the development of liver injury in GD patients.
- To evaluate the effectiveness of radioactive iodine ((131)I) therapy.
Main Methods:
- A cohort of 1,070 patients treated with (131)I therapy was studied.
- Pre-treatment assessments included thyroid function tests (FT4, TSH), antibody levels (TRAb, TgAb, TPOAb), radioactive iodine uptake (RAIU), and liver function tests.
- Statistical analyses included t-tests, chi-squared tests, logistic regression, and correlation.
Main Results:
- Patients with hepatic injury had higher age, longer GD duration, greater thyroid weight, and elevated FT4, TPOAb, and TRAb levels.
- Key risk factors identified were age, hyperthyroidism duration, heart rate, thyroid weight, FT4, TgAb, TPOAb, and TRAb.
- RAIU(24h) was found to be a protective factor against liver injury.
Conclusions:
- Specific patient profiles (age > 45, HR > 90 bpm, thyroid weight > 35g, GD duration > 3 years, FT4 > 70.5 pmol/l, TPOAb > 360 IU/ml, TRAb > 15 IU/l) indicate an increased risk of hepatic injury.
- (131)I therapy emerged as the most effective treatment option for Graves' disease patients with hepatic function injury.
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