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The active site of cytochrome P-450 nifedipine oxidase: a model-building study
1Physical Chemistry Laboratory, Oxford University, UK.
Journal of Molecular Graphics
|December 1, 1989
Abstract:
A model of the active site of cytochrome P-450 nifedipine oxidase is built on the basis of sequence homology with cytochrome P-450CAM. Substrates are docked into the binding pocket, and molecular mechanical energy minimization is performed to analyze the forces between the substrates and the enzyme.