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A computer graphics study of multistranded DNA models.

S McGavin1, H E Bosshard, C Carlson

  • 1Chemistry Department, University of Dundee, Scotland.

Journal of Molecular Graphics
|December 1, 1989
PubMed
Summary
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Computer graphics models reveal novel nucleic acid structures. Researchers explored relationships between models based on a core structure, identifying two main classes with specific base-pairing properties.

Area of Science:

  • Structural Biology
  • Computational Chemistry
  • Molecular Modeling

Background:

  • The study explores nucleic acid structures beyond canonical forms.
  • Utilizes computer graphics for detailed molecular modeling.
  • Focuses on the relationship between different nucleic acid models.

Purpose of the Study:

  • To build and analyze a range of related nucleic acid models.
  • To understand the structural relationships based on a "core" structure.
  • To classify models based on sugar-phosphate chain attachment to base layers.

Main Methods:

  • Development of nucleic acid models using a computer graphics system.
  • Analysis of structural relationships, including twofold rotation axes.
  • Classification of models into two principal groups based on chain attachment.

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Main Results:

  • A four-strand nucleic acid model with specific twofold rotation symmetry was detailed.
  • Models were categorized based on whether sugar-phosphate chains attach to every or alternate base layers.
  • Several models exhibited specificity in both base complementarity and identity.

Conclusions:

  • The study presents a systematic classification of novel nucleic acid structures.
  • The "core" structure provides a framework for understanding structural diversity.
  • Identified models demonstrate specific base-pairing interactions crucial for molecular recognition.