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Oculogyric crisis associated with disulfiram-induced pallidonigral lesion

Jae Hyeok Lee1, Chul Hyoung Lyoo2, Jin Goo Lee3

  • 1Department of Neurology, Pusan National University Yangsan Hospital, Yangsan, Korea.

Journal of Movement Disorders
|May 29, 2014
PubMed

Insights

Disulfiram intoxication can cause oculogyric crisis, a condition affecting eye movements. Brain imaging revealed basal ganglia and substantia nigra lesions, suggesting a link between these brain areas and the crisis.

Area of Science:

  • Neuroscience
  • Neurology
  • Toxicology

Background:

  • Disulfiram is used to treat alcohol dependence.
  • Oculogyric crisis is a rare extrapyramidal side effect characterized by tonic deviation of the eyes.

Purpose of the Study:

  • To report a case of oculogyric crisis following disulfiram intoxication.
  • To investigate the neuroanatomical basis of this adverse reaction.

Main Methods:

  • Case report of a patient with oculogyric crisis after disulfiram exposure.
  • Brain Magnetic Resonance Imaging (MRI) to identify structural lesions.

Main Results:

  • The patient developed oculogyric crisis one month after disulfiram intoxication.
  • Brain MRI revealed lesions in the bilateral globus pallidus and left substantia nigra.
  • These affected areas are critical components of the basal ganglia circuitry.

Conclusions:

  • Disulfiram intoxication can lead to oculogyric crisis.
  • Pathological reorganization of basal ganglia circuits, affecting the globus pallidus and substantia nigra, may underlie the observed ocular motor dysfunction.
Keywords:
DisulfiramOculogyric crisis

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