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Action tremor associated with lamotrigine monotherapy.
Ji-Hye Yang1, Sung-Woo Chung1, Joong-Seok Kim1
1Department of Neurology, The Catholic University of Korea, College of Medicine, Seoul St. Mary's Hospital, Seoul, Korea.
Journal of Movement Disorders
|May 29, 2014
Summary
Lamotrigine monotherapy rarely causes tremor. This case report details a patient experiencing positional and action tremor, suggesting a potential link to lamotrigine
Area of Science:
- Neurology
- Pharmacology
Background:
- Lamotrigine (LTG) is an anticonvulsant medication.
- LTG is known to cause tremor when combined with valproic acid.
- Tremor as a side effect of lamotrigine monotherapy is uncommon.
Purpose of the Study:
- To report a rare case of tremor associated with lamotrigine monotherapy.
- To investigate the potential mechanisms underlying lamotrigine-induced tremor.
Main Methods:
- Case report presentation.
- Analysis of temporal relationship between lamotrigine initiation and tremor onset.
Main Results:
- A patient developed positional and action tremor during lamotrigine monotherapy.
- The tremor resolved upon discontinuation or dose adjustment of lamotrigine (details not provided in abstract).
Conclusions:
- Lamotrigine monotherapy can, in rare instances, cause tremor.
- Potential mechanisms include increased serotonin transmission or altered basal ganglia dopamine activity.
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