Restlessness with Manic Episodes due to Right Parietal Infarction

Area of Science:

• Neurology
• Neuropsychiatry

Background:

• Mood disorders, including depression and anxiety, are frequent sequelae of acute stroke.
• Restlessness with manic episodes following stroke is an uncommon but significant clinical presentation.

Purpose of the Study:

• To report a rare case of post-stroke mania associated with a right parietal lobe infarction.
• To review existing literature on lesions implicated in post-stroke mania.
• To contribute to understanding the neurobiological mechanisms of mania after stroke.

Main Methods:

• Case report of a patient experiencing restlessness with manic episodes after acute stroke.
• Literature review of reported cases of post-stroke mania and associated lesion locations.

Main Results:

• The patient presented with restlessness and manic episodes following an acute infarction in the right parietal lobe.
• Previous reports indicate that lesions in the thalamus, caudate nucleus, and temporal and frontal lobes can precipitate post-stroke mania.

Conclusions:

• Right parietal lobe infarction is a novel location associated with post-stroke mania.
• This case highlights the diverse neuroanatomical substrates that can underlie mania after stroke.
• Further research is needed to elucidate the specific pathways involved in post-stroke manic presentations.