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Related Concept Videos

Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

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Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
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Nephrotic Syndrome II : Assessment and Medical Management01:26

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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

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In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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Acute Pyelonephritis II: Diagnostic Studies and Management01:28

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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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Acute Kidney Injury VI: Nursing Management01:22

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Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
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Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
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Related Experiment Video

Updated: Apr 29, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Pediatric lupus nephritis: Management update.

Rajiv Sinha1, Sumantra Raut1

  • 1Rajiv Sinha, Division of Pediatric Nephrology, Department of Pediatrics, Institute of Child Health, Kolkata 700017, India.

World Journal of Nephrology
|May 29, 2014
PubMed
Summary

Childhood-onset systemic lupus erythematosus (cSLE) impacts multiple organs, frequently affecting kidneys. Current treatments for lupus nephritis in children have limitations, prompting exploration of novel therapies.

Keywords:
CyclophosphamideLupus nephritisManagementMonoclonal antibodyMycophenolate mofetilPediatric

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Area of Science:

  • Pediatric Rheumatology
  • Nephrology
  • Immunology

Background:

  • Childhood-onset systemic lupus erythematosus (cSLE) is a severe autoimmune condition.
  • Kidney involvement (lupus nephritis) is common and can be fatal in cSLE patients.
  • Renal biopsy is crucial for managing lupus nephritis.

Purpose of the Study:

  • To review the current treatment protocols for childhood lupus nephritis.
  • To highlight the limitations of existing therapies and the need for novel agents.
  • To discuss the challenges in establishing a consensus for managing pediatric lupus nephritis.

Main Methods:

  • Review of existing literature on cSLE and lupus nephritis treatment.
  • Analysis of treatment outcomes with steroids and cyclophosphamide.
  • Discussion of emerging immunomodulatory and monoclonal antibody therapies.

Main Results:

  • Steroid treatment for childhood lupus nephritis is linked to poor outcomes and side effects.
  • Cyclophosphamide improves disease control but adherence can be an issue.
  • Novel agents are being investigated due to treatment failures with conventional drugs.

Conclusions:

  • Managing pediatric lupus nephritis is challenging due to treatment limitations and lack of adherence.
  • Novel immunomodulatory and monoclonal antibody therapies show promise but require further pediatric trials.
  • A consensus on the management protocol for pediatric lupus nephritis is difficult to establish.