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Clinical trial networks in orthopaedic surgery
A Rangan1, L Jefferson2, P Baker1
1The James Cook University Hospital, Marton Road, Middlesborough, TS4 3BW, UK.
Bone & Joint Research
|May 30, 2014
Summary
Clinical trial networks are vital for advancing orthopaedic surgery research. These networks facilitate multicentre randomized controlled trials (RCTs), crucial for disseminating and adopting research findings.
Area of Science:
- Orthopaedic Surgery
- Clinical Trials
- Research Networks
Background:
- Clinical trial networks are increasingly recognized for their role in orthopaedic surgery.
- Existing literature highlights the importance of infrastructure and collaboration.
Purpose of the Study:
- To review the role and impact of clinical trial networks in orthopaedic surgery.
- To examine how these networks support the conduct and dissemination of research.
Main Methods:
- Systematic literature search of MEDLINE and EMBASE databases up to September 2013.
- Inclusion of articles on randomized controlled trials (RCTs), research networks, and orthopaedic research.
- Narrative synthesis of findings under key themes.
Main Results:
- Identified 12 relevant studies from 818 initial titles.
- Highlighted the importance of networks in identifying research questions, education, conducting multicentre RCTs, and disseminating results.
- Confirmed the growing international awareness of network significance.
Conclusions:
- Clinical trial networks play a crucial role in supporting orthopaedic surgery research.
- Multidisciplinary collaboration and investment in trial infrastructure are essential for successful RCT delivery.
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