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[The empty follicle syndrome: a biologic reality]
Ginecologia Y Obstetricia De Mexico
|September 1, 1989
Summary
Empty Follicle Syndrome (EFS) may cause infertility, even with excellent ovarian response to stimulation. This condition, where no oocytes are retrieved despite mature follicles, warrants further investigation in infertile populations.
Area of Science:
- Reproductive Endocrinology
- Infertility Research
- Assisted Reproductive Technologies
Context:
- Gamete Intrafallopian Transfer (GIF) program involves ovulation stimulation.
- Patients received Clomiphene Citrate and human menopausal gonadotropin (hMG) for stimulation.
- Human chorionic gonadotropin (hCG) administered at 18 mm follicle size.
Purpose:
- To investigate the phenomenon of "Empty Follicle Syndrome" (EFS).
- To explore potential causes of unexplained infertility.
- To report on cases with excellent ovarian response but no oocyte retrieval.
Summary:
- Two patients in a GIF program showed excellent estradiol response (1,127 pg/ml) after stimulation.
- Despite mature follicles (≥18 mm) and hCG administration, 17 follicles yielded no oocytes.
- Findings suggest EFS may be a contributing factor to infertility.
Impact:
- Highlights EFS as a potential cause of treatment failure in assisted reproduction.
- Emphasizes the need for further research into EFS mechanisms.
- Contributes to understanding unexplained infertility causes.