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Updated: Apr 29, 2026

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
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Correlations between serum IL33 and tumor development: a meta-analysis.

Xiang-Jun Chen1, Ying-De Huang, Nian Li

  • 1Department of Medical Quality Control, West China Hospital, Sichuan University, Chengdu, China E-mail : drchan_hxyy@mcwcums. com.

Asian Pacific Journal of Cancer Prevention : APJCP
|May 30, 2014
PubMed
Summary
This summary is machine-generated.

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Interleukin-33 (IL-33) levels are higher in tumor patients compared to healthy individuals. While IL-33 shows potential for tumor detection, it does not correlate with tumor stage, metastasis, or survival time.

Area of Science:

  • Oncology
  • Immunology

Background:

  • Interleukin-33 (IL-33) is increasingly recognized for its role in tumor development.
  • Understanding the clinical significance of IL-33 in cancer is crucial.

Purpose of the Study:

  • To systematically evaluate the association between Interleukin-33 (IL-33) and tumor development.
  • To explore the potential of IL-33 as a biomarker for tumor detection and prognosis.

Main Methods:

  • A comprehensive meta-analysis was conducted.
  • Data was systematically gathered from multiple databases including PubMed, EMBASE, and Web of Science.
  • Eight relevant studies were included after rigorous quality assessment and data extraction.

Main Results:

  • Elevated IL-33 levels were observed in patients with tumors compared to healthy controls.

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  • No significant correlation was found between IL-33 levels and tumor stage, metastasis, or patient survival time.

    • Conclusions:

    • Interleukin-33 (IL-33) may serve as a valuable alarm factor for tumor detection.
    • Further research is needed to fully elucidate the prognostic implications of IL-33 in oncology.