Related Experiment Video
Updated: Apr 29, 2026
12:03
Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
Published on: June 7, 2016
17.3K
[Renin-aldosterone and bone metabolism].
1National Center for Geriatrics and Gerontology, Japan.
Clinical Calcium
|May 30, 2014
Summary
The renin-angiotensin-aldosterone system (RAAS) regulates blood pressure and fluid balance. Key RAAS components are drug targets, linking to inflammation, injury, and metabolism.
Area of Science:
- Biochemistry
- Physiology
- Pharmacology
Context:
- The renin-angiotensin-aldosterone system (RAAS) is crucial for blood pressure and fluid homeostasis.
- Components like renin, angiotensin II, and aldosterone are established drug targets.
Purpose:
- To explore the multifaceted roles of the RAAS beyond blood pressure regulation.
- To highlight the connections between RAAS and various physiological processes.
Summary:
- The RAAS involves key components such as renin, angiotensin II (and its AT1/2 receptors), and aldosterone (and its mineralocorticoid receptor).
- These components have been successfully targeted in drug development.
- Emerging evidence links the RAAS, via systemic and local pathways, to inflammation, oxidative stress, cardiovascular and renal damage, and calcium/bone metabolism.
Impact:
- Provides a comprehensive overview of RAAS involvement in diverse physiological and pathological conditions.
- Underscores the potential for novel therapeutic strategies targeting the RAAS.
- Facilitates understanding of RAAS interactions in cardiovascular, renal, and metabolic diseases.
Related Concept Videos
01:33Hormonal Regulation
30.3K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
30.3K
01:13Introduction to Urinary System
11.2K
The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
11.2K
01:25Antihypertensive Drugs: Direct Renin Inhibitors
1.8K
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
1.8K
01:31Osteoclasts in Bone Remodeling
3.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.9K
01:30Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
2.7K
Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
2.7K
01:29Hypertension II: Pathophysiology
1.7K
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.7K