Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Key Techniques in Microbiology01:19

Key Techniques in Microbiology

2.1K
Aseptic techniques prevent contamination, ensure experimental accuracy, and protect researchers and microbial cultures. These techniques are essential in clinical, industrial, and research settings where sterility is required.Maintaining Sterility in Laboratory PracticesScientists maintain sterility by sterilizing tools with heat or chemicals, disinfecting work surfaces, and handling cultures in controlled environments. Working near an open flame or within a laminar flow hood reduces the risk...
2.1K
Matrix Proteoglycans and Glycoproteins01:21

Matrix Proteoglycans and Glycoproteins

5.0K
Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers associated with large amounts of proteoglycans. These proteoglycans have long negative charges that attract cations, which in turn attract water molecules. This influx of ions and water molecules swells up the proteoglycan like a water-soaked gel that can...
5.0K
Proteoglycans01:05

Proteoglycans

4.7K
Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
4.7K
The Extracellular Matrix01:42

The Extracellular Matrix

88.5K
Overview
88.5K
Key Elements for Plant Nutrition02:35

Key Elements for Plant Nutrition

24.1K
Like all living organisms, plants require organic and inorganic nutrients to survive, reproduce, grow and maintain homeostasis. To identify nutrients that are essential for plant functioning, researchers have leveraged a technique called hydroponics. In hydroponic culture systems, plants are grown—without soil—in water-based solutions containing nutrients. At least 17 nutrients have been identified as essential elements required by plants. Plants acquire these elements from the...
24.1K
pH Regulation in Cells01:28

pH Regulation in Cells

7.6K
pH plays a critical role in maintaining normal cellular activities. It helps maintain the structure and function of various proteins, dictates the charge on cellular membranes, and is crucial for metabolic reactions inside the cell. Moreover, cells use the energy from the proton motive force to generate ATP.
Cytosolic pH
Under physiological conditions, the cytosolic pH is slightly more acidic than the extracellular pH. However, cells must prevent further acidification of their cytosol to...
7.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney" [Matrix Biology 68-69 (2018) 293-317].

Matrix biology : journal of the International Society for Matrix Biology·2026
Same author

Corrigendum to "Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury." Kidney International 2019;95:540-562.

Kidney international·2026
Same author

Inhibition of FXIIa attenuates kidney fibrosis in mice with unilateral ureteral obstruction.

Cellular and molecular life sciences : CMLS·2025
Same author

The Powerful Impact of Interdisciplinary Collaboration Between Societies.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society·2025
Same author

Challenges in mimicking hypoxia: insights into HIF-regulated MiRNA expression induced by DMOG and CoCl<sub>2</sub>.

Cell communication and signaling : CCS·2025
Same author

Deletion of ABIN1-LIR motifs impairs hepatic lipid homeostasis and mitophagy via AMPK-TFEB axis in mice.

American journal of physiology. Cell physiology·2025

Related Experiment Video

Updated: Jan 26, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.6K

Proteoglycans, key regulators of cell-matrix dynamics.

Liliana Schaefer1

  • 1Pharmazentrum Frankfurt, Institut für Allgemeine Pharmakologie und Toxikologie, Klinikum der Goethe-Universität Frankfurt am Main, Haus 74, Z. 3.108a, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.

Matrix Biology : Journal of the International Society for Matrix Biology
|May 30, 2014
PubMed
Summary

This special issue explores proteoglycan biology, covering hyaluronan metabolism, proteoglycan pathways, and their roles in inflammation, cancer, repair, and development. Leading researchers present cutting-edge reviews and original work to advance this dynamic field.

More Related Videos

Micromanipulation Techniques Allowing Analysis of Morphogenetic Dynamics and Turnover of Cytoskeletal Regulators
12:52

Micromanipulation Techniques Allowing Analysis of Morphogenetic Dynamics and Turnover of Cytoskeletal Regulators

Published on: May 12, 2018

10.5K
Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis
12:44

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis

Published on: November 11, 2014

12.7K

Related Experiment Videos

Last Updated: Jan 26, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.6K
Micromanipulation Techniques Allowing Analysis of Morphogenetic Dynamics and Turnover of Cytoskeletal Regulators
12:52

Micromanipulation Techniques Allowing Analysis of Morphogenetic Dynamics and Turnover of Cytoskeletal Regulators

Published on: May 12, 2018

10.5K
Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis
12:44

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis

Published on: November 11, 2014

12.7K

Area of Science:

  • Proteoglycan biology and its broad impact across biological disciplines.

Background:

  • The field of proteoglycanology has significantly expanded over the last three decades.
  • Proteoglycans are crucial molecules involved in diverse biological processes.

Framework:

  • This special issue is structured into five chapters.
  • Content covers hyaluronan metabolism, proteoglycan biosynthesis, and catabolism.

Implementation:

  • Includes original research and comprehensive reviews from experts.
  • Focuses on the multifaceted roles of proteoglycans.

Implications:

  • Aims to stimulate further research in the exciting field of proteoglycan biology.
  • Highlights the importance of proteoglycans in inflammation, cancer, development, and tissue repair.