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Homozygosity for 8pter----q22 in acute myeloblastic leukemia with t(8;21)(q22;q22)
1Unité INSERM U301, et L.O.I. CNRS, Hôpital Saint Louis, Paris, France.
Genes, Chromosomes & Cancer
|September 1, 1989
Abstract:
A case of acute nonlymphocytic leukemia with homozygosity for the chromosome segment 8pter----8q22 is reported. A t(8;21)(q22;q22) translocation was associated with duplication of the derivative chromosome 8q- and absence of the normal chromosome 8. These rearrangements also yielded hemizygosity for 8q22----qter. This case shows that acquired hemizygosity and homozygosity do exist in leukemia as in solid malignant tumors.