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Cohort Profile: The Japanese Population-based Osteoporosis (JPOS) Cohort Study
Masayuki Iki1, Junko Tamaki2, Yuho Sato2
1Department of Public Health, Kinki University Faculty of Medicine, Osaka-Sayama, Japan, Department of Hygiene and Public Health, Osaka Medical College, Takatsuki, Japan, Department of Human Life, Jin-ai University, Echizen, Japan, Department of Nutrition, Koshien University, Takarazuka, Japan, Centre for Occupational Safety and Health Management, Kinki University Hospital, Osaka-Sayama, Japan, Department of Public Health and Home Nursing, Graduate School of Medical Sciences, Nagoya University, Nagoya, Japan, Toyama Pharmaceutical Association, Toyama, Japan, Department of Blood Purification and Internal Medicine, Kidney Centre, Tokyo Women's Medical University, Tokyo, Japan, Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medical Sciences, Tokushima, Japan, Toyama University, Toyama, Japan, Kagawa Nutrition University, Tokyo, Japan and Shuuwa General Hospital, Kasukabe, Japan masa@med.kindai.ac.jp.
Abstract:
The Japanese Population-based Osteoporosis (JPOS) Cohort Study was launched in 1996 to produce a reference database of areal bone mineral density (aBMD) by dual energy X-ray absorptiometry (DXA) and bone turnover markers in the Japanese female population and to determine risk factors for osteoporotic fractures. At baseline, 3984 women aged 15 to 79 years were randomly selected to provide representative bone status data and aBMD values for the diagnosis of osteoporosis. Follow-up surveys were conducted in 1999, 2002, 2006 and 2011/12 to determine changes in aBMD and identify incident morphometry-confirmed vertebral fractures and clinical fractures. These outcomes were obtained from 2174 women who participated in at least one follow-up survey. JPOS is a unique resource of individual-level bone health information with radiological and biological archives that include DXA images, and serum, plasma and DNA for future analyses with emerging radiological and biological techniques. The JPOS dataset is not freely available, but new collaborations are encouraged. Potential collaborators are invited to contact the Secretary General (M.I.) at the administrative office of the JPOS Study Group.
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