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Carolyn A Allan1, Veronica R Collins2, Mark Frydenberg3

  • 1MIMR-PHI Institute of Medical Research27-31 Wright Street, Clayton, Victoria 3168, AustraliaAndrology AustraliaSchool of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, AustraliaDepartment of EndocrinologyMonash Health, Melbourne, Victoria, AustraliaDepartments of Obstetrics and GynaecologySurgeryMonash University, Clayton, Victoria, AustraliaDepartment of UrologyMedical ProgramMonash Health, Melbourne, Victoria, AustraliaMIMR-PHI Institute of Medical Research27-31 Wright Street, Clayton, Victoria 3168, AustraliaAndrology AustraliaSchool of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, AustraliaDepartment of EndocrinologyMonash Health, Melbourne, Victoria, AustraliaDepartments of Obstetrics and GynaecologySurgeryMonash University, Clayton, Victoria, AustraliaDepartment of UrologyMedical ProgramMonash Health, Melbourne, Victoria, AustraliaMIMR-PHI Institute of Medical Research27-31 Wright Street, Clayton, Victoria 3168, AustraliaAndrology AustraliaSchool of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, AustraliaDepartment of EndocrinologyMonash Health, Melbourne, Victoria, AustraliaDepartments of Obstetrics and GynaecologySurgeryMonash University, Clayton, Victoria, AustraliaDepartment of UrologyMedical ProgramMonash Health, Melbourne, Victoria, AustraliaMIMR-PHI Institute of Medical Research27-31 Wright Street, Clayton, Victoria 3168, AustraliaAndrology AustraliaSchool of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, AustraliaDepartment of EndocrinologyMonash Health, Melbourne, Victoria, AustraliaDepartments of Obstetrics and GynaecologySurgeryMonash University, Clayton, Victoria, AustraliaDepartment of UrologyMedical ProgramMonash Health, Melbourne, Victoria, Australia carolyn.allan@mimr-phi.org.

Endocrine-Related Cancer
|May 30, 2014
PubMed
Summary

Androgen deprivation therapy (ADT) for prostate cancer significantly impacts quality of life and health. It increases risks for bone loss, metabolic issues like diabetes, and cardiovascular events, requiring careful patient monitoring.

Keywords:
androgen deprivation therapybonecardiovascular diseasediabetesfractureosteoporosisprostate cancerquality of life

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Area of Science:

  • Oncology
  • Endocrinology
  • Men's Health

Background:

  • Androgen deprivation therapy (ADT) is a cornerstone treatment for advanced prostate cancer.
  • ADT suppresses testosterone, leading to significant side effects impacting patient well-being.

Purpose of the Study:

  • To review the adverse effects of ADT on quality of life, bone health, and cardio-metabolic parameters.
  • To highlight the increased risks associated with prolonged hypoandrogenism from ADT.

Main Methods:

  • Review of cross-sectional and longitudinal studies examining ADT's impact.
  • Analysis of observational evidence on ADT's association with various health risks.

Main Results:

  • ADT accelerates bone loss, increasing osteoporosis and fracture risk.
  • Adverse effects include increased fat mass, reduced lean mass, dyslipidemia, insulin resistance, and type 2 diabetes risk.
  • Increased risk of cardiovascular events observed, though cardiovascular mortality link remains uncertain.

Conclusions:

  • Men on ADT face higher risks of psychosexual dysfunction, osteoporotic fracture, diabetes, and cardiovascular disease, particularly with long-term treatment.
  • Healthcare providers must be vigilant about ADT's potential risks and implement appropriate monitoring and management strategies.