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Related Experiment Videos

Autoperfusing ectothermic heart-lung preservation system.

J Y Kresh1, S K Brockman

  • 1Department of Cardiothoracic Surgery, Likoff Cardiovascular Institute, Hahnemann University, Philadelphia, PA 19102-1192.

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
|January 1, 1989
PubMed
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Correction.

Journal of investigative surgery : the official journal of the Academy of Surgical Research·2026
See all related articles

A portable heart-lung preservation system allows distant organ procurement. Ectothermic pH regulation enables viable heart-lung function for over 6 hours, preventing allograft failure.

Area of Science:

  • Cardiovascular Surgery
  • Organ Transplantation
  • Biomedical Engineering

Background:

  • Distant organ procurement is limited by preservation time.
  • Maintaining heart-lung viability ex vivo is crucial for transplantation.

Purpose of the Study:

  • To develop a portable system for ex vivo heart-lung preservation.
  • To assess the viability of a working heart-lung system during preservation.

Main Methods:

  • A portable, temperature-controlled chamber was used for isolated canine heart-lung systems.
  • Perfusion utilized an autologous blood reservoir with controlled cardiac output (CO).
  • Physiological parameters including intramyocardial tissue pressure (IMP) and pH were monitored.

Main Results:

Related Experiment Videos

  • Normothermic autoperfusion led to pulmonary dysfunction within 3 hours.
  • Ectothermic pH regulation (alpha-stat) enabled stable heart-lung function (>6 hours) at reduced temperatures (17-28°C).
  • Reduced CO (30-50% of normal) and ectothermic pH control maintained myocardial viability and prevented fibrillation.

Conclusions:

  • A portable heart-lung preservation system can support a working organ ex vivo for extended periods.
  • Ectothermic pH modulation is key to reducing metabolic demand and preventing allograft failure.
  • This system facilitates distant organ procurement and improves transplantation outcomes.