Related Experiment Video
Updated: Apr 28, 2026

Mouse Round Spermatid Injection
Published on: January 26, 2024
[UBE2B gene and male infertility: an update]
Abstract:
Male infertility is a worldwide problem, and about 15% of the cases are associated with spermatogenesis-related gene mutation. The mammalian gene UBE2B is the homolog of the RAD6 gene of yeast, belonging to the ubiquitin proteasome system and playing an important role in spermatogenesis. Mice lacking the UBE2B gene are infertile, with reduced sperm motility, increased morphologically abnormal sperm, and inhibited meiosis of spermatogonia. Accumulated evidence shows that UBE2B gene mutants and single nucleotide polymorphisms are associated with male infertility. This article reviews the relation between the UBE2B gene and male infertility, offering some theoretical evidence for the diagnosis and treatment of male infertility.
Related Concept Videos
Infertility in Males
Infertility in Females
Endometriosis, a condition characterized by abnormal growth of...
Microbiota of the Urogenital Tract
Sex-linked Disorders
Nondisjunction
Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....

