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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Updated: Apr 28, 2026

Measuring Local Anaphylaxis in Mice
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Anaphylaxis as occupational risk.

Gianna Moscato1, Gianni Pala, Mariangiola Crivellaro

  • 1aDepartment of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia bOccupational Physician's Division, Local Health Authority of Sassari, Sassari cDepartment of Cardiologic, Thoracic and Vascular Sciences, University of Padua, Padua dFormerly Occupational Allergology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.

Current Opinion in Allergy and Clinical Immunology
|May 31, 2014
PubMed
Summary

Occupational anaphylaxis (OcAn) is a severe allergic reaction triggered by workplace exposures. Key triggers include Hymenoptera venom and natural rubber latex, necessitating emergency preparedness and potential immunotherapy.

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Area of Science:

  • Allergy and Immunology
  • Occupational Health
  • Toxicology

Background:

  • Anaphylaxis is a life-threatening allergic reaction.
  • Occupational anaphylaxis (OcAn) is triggered by workplace exposures.
  • Common anaphylaxis triggers can also cause OcAn.

Purpose of the Study:

  • To summarize current scientific evidence on OcAn.
  • To review literature on OcAn published in 2012 and 2013.

Main Methods:

  • Literature review of scientific evidence on OcAn.
  • Focused review of publications from 2012-2013.

Main Results:

  • Hymenoptera venom and natural rubber latex are primary OcAn triggers.
  • Other triggers include foods, insects, snakes, chemicals, and medications.
  • Recent literature covers immunological contact urticaria and Hymenoptera venom immunotherapy.

Conclusions:

  • OcAn is a serious occupational health concern with identified triggers and at-risk occupations.
  • Emergency management plans, adrenaline availability, and trained personnel are crucial.
  • Venom immunotherapy is recommended for Hymenoptera venom-allergic patients.