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Updated: Apr 28, 2026

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
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Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

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A novel decoy receptor fusion protein for FGF-2 potently inhibits tumour growth

D Li1, X Wei1, K Xie1

  • 1School of Life Sciences and Technology, Tongji University, 1239 Siping Road, Shanghai 200092, China.

British Journal of Cancer
|May 31, 2014
PubMed
Abstract

Insights

A novel fusion protein, Fibroblast growth factor-Trap, effectively inhibits tumor growth by blocking Fibroblast growth factor-2 (FGF-2) signaling. This targeted antiangiogenic therapy shows promise for cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biotechnology

Background:

  • Antiangiogenic therapies are crucial for cancer treatment.
  • Fibroblast growth factor-2 (FGF-2) drives tumor angiogenesis and is a key therapeutic target.
  • Developing novel FGF-2 inhibitors is essential for advancing cancer therapy.

Purpose of the Study:

  • To develop a novel fusion protein inhibitor targeting FGF-2.
  • To identify a decoy receptor fusion protein with high binding affinity for FGF-2.
  • To evaluate the anti-tumorigenic potential of the developed inhibitor.

Main Methods:

  • Eleven fusion proteins were engineered by combining FGFR1 extracellular regions with the IgG1 Fc region.
  • An FGF-2 binding assay identified the optimal decoy receptor fusion protein.
  • In vitro and in vivo studies assessed the anti-tumorigenic effects of the lead candidate.

Main Results:

  • A soluble decoy receptor fusion protein, FGF-Trap, with high FGF-2 binding activity was developed.
  • FGF-Trap suppressed FGF-2-mediated signaling, including Erk1/2 and Akt phosphorylation, and VEGFR expression.
  • FGF-Trap inhibited endothelial cell proliferation and migration in vitro and suppressed tumor growth and angiogenesis in vivo.

Conclusions:

  • FGF-Trap effectively inhibits tumor growth by blocking FGF-2 signaling pathways.
  • This novel therapeutic agent demonstrates significant potential for treating cancer patients.
  • Targeting FGF-2 with engineered fusion proteins offers a promising antiangiogenic strategy.

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