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Updated: Apr 28, 2026
Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG
Published on: December 28, 2014
Effects of ischemia on free fatty acids and diacylglycerols in developing rat brain
1Sinclair Comparative Medicine Research Farm and Biochemistry Department, University of Missouri, Columbia, MO 65201, U.S.A.
Abstract:
Post-decapitative ischemic treatment imposed on the developing rat brain elicited a marked increase in its susceptibility to free fatty acid (FFA) release between 14 and 17 days, an observation similar to that reported by Bazan (Acta Physiol. Lat. Am.21, 15, 1971). Although the level of diacylglycerols (DG) also increased during this period, the extent of the increase was not as obvious as the FFA. Ischemic treatment to rats after 17 days of age elicited increases in DG and FFA enriched in stearic and arachidonic acids. The delayed response in susceptibility of brain tissue to ischemia-induced changes seems to suggest that the biochemical mechanism(s) responsible for the FFA and DG release is better correlated to events commensurating with synaptogenesis than with myelination.
