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Hepcidin quantification: methods and utility in diagnosis.

T Konz1, M Montes-Bayón, S Vaulont

  • 1Department of Physical and Analytical Chemistry, Faculty of Chemistry, University of Oviedo, C/Julian Clavería 8, 33006 Oviedo, Spain. montesmaria@uniovi.es.

Metallomics : Integrated Biometal Science
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PubMed
Summary
This summary is machine-generated.

Accurate measurement of hepcidin, a key hormone in iron balance, is crucial for diagnosing iron disorders. This review evaluates analytical methods for hepcidin testing and its clinical applications.

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Area of Science:

  • Biochemistry
  • Clinical Chemistry
  • Endocrinology

Background:

  • Hepcidin is a peptide hormone regulating iron homeostasis.
  • Accurate hepcidin measurement is vital for diagnosing iron-related disorders.
  • Various analytical methods exist for hepcidin quantification in biological fluids.

Purpose of the Study:

  • To critically review analytical methodologies for hepcidin determination.
  • To compare ELISA and mass spectrometry techniques for hepcidin analysis.
  • To revise current and emerging clinical applications of hepcidin testing.

Main Methods:

  • Evaluation of ELISA (competitive and sandwich formats).
  • Comparison of molecular mass spectrometry (MALDI, LC-MS).
  • Inclusion of elemental mass spectrometry (ICP-MS) as a complementary tool.

Main Results:

  • Analytical methods for hepcidin determination present ongoing challenges.
  • ELISA and mass spectrometry show distinct advantages and limitations.
  • Hepcidin testing is valuable for diagnosing iron deficiency anemia, anemia of chronic disease, and hemochromatosis.

Conclusions:

  • Standardized and accurate hepcidin assays are needed for reliable clinical application.
  • Hepcidin testing aids in diagnosing and managing various iron disorders.
  • Further research into hepcidin's role in cancer therapy response is warranted.