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Published on: June 13, 2020
Postnatal development of rat cerebellum: Glycosaminoglycan changes related to variation in water content, cell
G Normand1, J Clos2, G Vincendon1
1Institut de Chimie Biologique de la Faculté de Médicine, Université Louis Pasteur, 11 rue Humann, Israel; Centre de Neurochimie du CNRS, 5 rue Blaise Pascal, 67000 StrasbourgGermany.
Abstract:
Modifications of glycosaminoglycans were studied during rat cerebellum ontogenesis. Levels of both hyaluronic acid and sulphated glycosaminoglycans increase during development but not at the same rate as cerebellar size or proteins. As in the rest of the brain, cerebellar hyaluronic acid concentration decreases during development but not, as expected, in parallel with the loss of tissue water content. In contrast to forebrain, the concentration of cerebellar sulphated glycosaminoglycans decreases at a slow rate. The correlation, suggested by several authors, between glycosaminoglycans concentration and tissue hydratation, cell migration and myelination were not confirmed in developing rat cerebellum.
