Related Experiment Video
Updated: Apr 28, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
Oncogenic roles of EMT-inducing transcription factors
Alain Puisieux1, Thomas Brabletz2, Julie Caramel1
1Inserm UMR-S1052, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, F-69008 Lyon, France; Université Lyon 1, ISPB, F-69000 Lyon, France; and Centre Léon Bérard, F-69008 Lyon, France.
Abstract:
The plasticity of cancer cells underlies their capacity to adapt to the selective pressures they encounter during tumour development. Aberrant reactivation of epithelial-mesenchymal transition (EMT), an essential embryonic process, can promote cancer cell plasticity and fuel both tumour initiation and metastatic spread. Here we discuss the roles of EMT-inducing transcription factors in creating a pro-tumorigenic setting characterized by an intrinsic ability to withstand oncogenic insults through the mitigation of p53-dependent oncosuppressive functions and the gain of stemness-related properties.
Related Concept Videos
Master Transcription Regulators
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Transcription Factors
Transcription Factors
General Transcription Factors
Mitogens and the Cell Cycle

