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A centrosomal route for cancer genome instability

Guillermo de Cárcer1, Marcos Malumbres1

  • 1Cell Division and Cancer Group, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, E-28029 Madrid, Spain.

Nature Cell Biology
|May 31, 2014
PubMed
Summary

Cyclin B2 regulates a pathway crucial for preventing aneuploidy, a common feature in cancer. Its alteration leads to defective cell division, chromosomal instability, and tumor development.

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