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Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Heart Failure I: Introduction01:27

Heart Failure I: Introduction

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Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
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Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

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Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
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Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

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The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
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Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Association between locomotor muscle quality and cardiac function during exercise in heart failure with preserved ejection fraction.

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Tirzepatide Reduces LV Mass and Paracardiac Adipose Tissue in Obesity-Related Heart Failure: SUMMIT CMR Substudy.

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Related Experiment Video

Updated: Apr 28, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

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Right heart dysfunction in heart failure with preserved ejection fraction.

Vojtech Melenovsky1, Seok-Jae Hwang2, Grace Lin2

  • 1Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA Department of Cardiology, Institute of Clinical and Experimental Medicine - IKEM, Videnska 1958/9, Prague 4 140 28, Czech Republic vojtech.melenovsky@ikem.cz.

European Heart Journal
|May 31, 2014
PubMed
Summary
This summary is machine-generated.

Right heart dysfunction is common in heart failure with preserved ejection fraction (HFpEF). This condition significantly predicts mortality and may be a new therapeutic target.

Keywords:
Atrial fibrillationGenderHaemodynamicsHeart failurePulmonary hypertensionVentricular function

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Last Updated: Apr 28, 2026

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Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
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Area of Science:

  • Cardiology
  • Cardiovascular Physiology
  • Heart Failure Research

Background:

  • Right heart function is not well understood in heart failure with preserved ejection fraction (HFpEF).
  • Characterizing right ventricular dysfunction (RVD) is crucial for understanding HFpEF pathophysiology and prognosis.

Purpose of the Study:

  • To investigate the hemodynamic, clinical, and prognostic factors associated with RVD in HFpEF patients.
  • To compare right heart function between HFpEF patients and healthy controls.

Main Methods:

  • Right heart catheterization and echocardiography were performed on 96 HFpEF patients and 46 controls.
  • Follow-up data was collected to assess mortality.
  • Right ventricular function was evaluated using load-dependent and load-independent indices.

Main Results:

  • 33% of HFpEF patients exhibited RVD, associated with increased symptoms and comorbidities.
  • HFpEF patients showed impaired right ventricular function compared to controls.
  • RVD was the strongest predictor of death in HFpEF patients (HR: 2.4).

Conclusions:

  • Right heart dysfunction is prevalent in HFpEF, stemming from RV contractile issues and pulmonary hypertension.
  • RVD in HFpEF is linked to pulmonary artery pressures, atrial fibrillation, male sex, and left ventricular dysfunction.
  • Targeting RVD in HFpEF may offer a novel therapeutic approach.