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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: Apr 28, 2026

In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research

In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research

Published on: September 16, 2019

Endogenous antibodies for tumor detection.

Barrie S Rich¹, Joshua N Honeyman¹, David G Darcy²

¹1] Laboratory of Cellular Biophysics, The Rockefeller University, New York, NY 10065 [2] Division of Pediatric Surgery, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065 [3].

Scientific Reports

|May 31, 2014

Summary

Researchers discovered higher concentrations of endogenous gamma immunoglobulin (IgG) in cancerous organs of mice. This finding suggests potential for using these natural antibodies as biomarkers for cancer detection and therapy.

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Area of Science:

Cancer Immunology
Biomarker Discovery
Immunotherapy

Background:

Cancer immunology offers diagnostic and therapeutic tools via autoantibodies and monoclonal antibodies.
The presence and extent of endogenous antibodies within tumor tissues are not fully understood.

Purpose of the Study:

To investigate the concentration and distribution of endogenous antibodies in malignant tissues.
To explore the potential of endogenous antibodies as cancer biomarkers and therapeutic targets.

Main Methods:

Utilized transgenic and xenograft mouse models of cancer.
Quantified endogenous gamma immunoglobulin (IgG) levels in transformed versus non-transformed organs.
Compared IgG concentrations within the same mouse and against wild-type controls.

Main Results:

Endogenous IgG was found at significantly higher concentrations in malignantly transformed organs.
This enrichment was observed in both transgenic and xenograft mouse models.
Higher IgG levels were detected compared to non-transformed organs and organs from wild-type mice.

Conclusions:

Endogenous IgG enrichment in malignant tissues offers a novel approach for identifying and tracking cancer cells.
These findings support the development of diagnostic and therapeutic strategies targeting endogenous antibodies.
Further research can exploit these antibodies for in vivo cancer monitoring and treatment.