A simplified necropsy technique for mice: making the most of unscheduled deaths

Sudden or unexpected deaths in experimental mice can be potential causes of lost data or lost opportunities to diagnose health problems. In small animal units and in particular out of normal working hours there may not be the time or expertise available to attempt a careful dissection on unscheduled mortalities or moribund animals. This paper outlines a robust and easy necropsy technique which can be easily learnt, uses minimal equipment and can be used to implement the 3Rs (replacement, refinement and reduction) by maximizing the amount of information gained from experimental animals.