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Updated: Apr 28, 2026
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Depletion of Specific Cell Populations by Complement Depletion
Published on: February 5, 2010
23.1K
[Complement deficiencies and human diseases]
Jérémie Rosain1, Stéphanie Ngo1, Pauline Bordereau1
1Immunologie biologique, Hôpital européen Georges-Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France.
Annales De Biologie Clinique
|May 31, 2014
Summary
The complement system, crucial for immunity, can be deficient, increasing infection and autoimmune disease risks. Genetic testing and familial studies are vital for diagnosing and managing these complement deficiencies.
Area of Science:
- Immunology
- Biochemistry
Context:
- The complement system is a critical component of innate and adaptive immunity.
- It comprises serum and membrane proteins that interact in a regulated cascade.
- Its functions include antibacterial immunity, inflammation modulation, and immune complex clearance.
Purpose:
- To review the complement cascade.
- To discuss laboratory tests for assessing complement function.
- To outline major diseases linked to complement deficiencies.
Summary:
- Complement deficiencies, whether inherited or acquired, heighten susceptibility to bacterial infections and autoimmune disorders.
- While basic screening is possible, specialized laboratory diagnosis and genetic testing are often necessary.
- Congenital deficiencies warrant familial studies and prophylactic measures.
Impact:
- Highlights the clinical significance of complement system defects.
- Emphasizes the importance of timely diagnosis and genetic analysis.
- Provides a comprehensive overview for clinicians and researchers in immunology and related fields.
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