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Updated: Apr 28, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
[Immunogenetics of nasopharyngeal carcinoma]
Arij Ben Chaaben1, Hajer Abaza2, Hayet Douik2
1Laboratoire de biologie clinique, Institut Salah Azaiz, Tunis, Tunisie, Laboratoire Jean Dausset d'immunologie et d'histocompatibilité, CIB-HOG, AP-HP et IUH, Inserm U940 Hôpital Saint-Louis, Paris, France.
Abstract:
Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factors. Genetic predisposition linked to the immune system has been associated with various tumors. This involves genetic diversity of the genes encoding the molecules of the immune response such as inflammation and anti-tumor surveillance. In this work, we examined the impact of the immunogenetic diversity on the risk of the NPC in different populations studied. These data show that the interindividual variability of the genetic regulation of immune processes increases the risk of NPC in individuals previously predisposed due to other risk factors (genetic / environmental). This synthesis, in addition to the predictive aspects, could provide innovative research for the development of new therapeutic approaches.
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