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Related Experiment Video

Updated: Apr 28, 2026

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Interleukin-8 is associated with acute and persistent dysfunction after optic neuritis.

S Rossi1, C Motta1, V Studer1

  • 1Clinica Neurologica, Dipartimento di Medicina dei Sistemi, Università Tor Vergata, Italy/Fondazione Santa Lucia/Centro Europeo per la Ricerca sul Cervello (CERC), Italy.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|May 31, 2014
PubMed
Summary

Interleukin-8 (IL-8) levels in cerebrospinal fluid correlate with vision loss and optic nerve damage in acute optic neuritis patients. Higher IL-8 indicates poorer visual outcomes and persistent neurodegeneration.

Keywords:
Cerebrospinal fluidIL-8OCTinflammationmultiple sclerosisvisual-evoked potentials

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Area of Science:

  • Neuroimmunology
  • Ophthalmology
  • Neuroinflammation

Background:

  • Acute optic neuritis is frequently linked to multiple sclerosis (MS).
  • Proinflammatory cytokines are implicated in neuroinflammation but their role in optic neuritis is understudied.

Purpose of the Study:

  • To investigate the association between intrathecal proinflammatory cytokine levels and optic neuritis outcomes.
  • To determine the relationship between cytokine levels and transient/persistent visual dysfunction.

Main Methods:

  • Cerebrospinal fluid (CSF) levels of IL-1β, TNF, and IL-8 were measured in 50 MS patients.
  • Clinical, neurophysiological (VEP), and morphological (OCT) measures assessed optic neuritis severity.
  • Patients were followed for up to six months.

Main Results:

  • Elevated IL-8 levels correlated with visual impairment (visual acuity, VEP latency).
  • IL-8 was associated with persistent demyelination and axonal loss.
  • Higher IL-8 levels predicted poorer final visual acuity and incomplete recovery.

Conclusions:

  • IL-8 is identified as a key inflammatory cytokine in optic neuritis.
  • IL-8 is linked to demyelination and secondary neurodegeneration in the optic nerve.
  • This finding highlights IL-8's potential as a biomarker for optic neuritis prognosis.