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Murine Ileocolic Bowel Resection with Primary Anastomosis
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Published on: October 29, 2014

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Ipilimumab-induced colonic perforation

Lyle Burdine1, Keith Lai2, Jonathan A Laryea3

  • 1Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA ljburdine@uams.edu.

Journal of Surgical Case Reports
|May 31, 2014
PubMed

Biologic immune modulators such as ipilimumab have demonstrated the efficacy against metastatic melanoma. We present a recent case of a 52-year-old male who initially developed mild colitis following the initiation of ipilimumab treatment for metastatic melanoma. Despite initial improvement with immediate cessation of drug and initiation of high-dose steroid therapy his clinical condition worsened and the patient presented to our facility in extremis from colonic perforation. Following an extended right hemicolectomy his postoperative period was extended due to continued symptomatic enteritis. After 3 weeks colonoscopy revealed that the autoimmune event had begun to subside;  his condition improved, resulting in discharge. We discuss this particular side effect with respect to ipilimumab adjuvant therapy in melanoma.

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