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Updated: Apr 28, 2026

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

New tools for embryo selection: comprehensive chromosome screening by array comparative genomic hybridization.

Lorena Rodrigo¹, Emilia Mateu¹, Amparo Mercader²

¹IVIOMICS SPAIN, Parc Cientific Universitat de València, Calle Catedrático Agustín Escardino 9, 46980 Valencia, Spain ; Instituto Valenciano de Infertilidad (IVI), Instituto Universitario IVI/INCLIVA, Plaza de la Policía Local 3, 46015 Valencia, Spain.

Biomed Research International

|May 31, 2014

Summary

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Comprehensive chromosome screening (CCS) using array comparative genomic hybridization (aCGH) shows consistent implantation and pregnancy rates. However, advanced maternal age impacts delivery rates due to higher aneuploidy, affecting embryo implantation success.

Area of Science:

Reproductive Medicine
Genetics
Embryology

Background:

Recurrent miscarriage, implantation failure, and advanced maternal age are significant challenges in assisted reproductive technologies.
Chromosomal abnormalities in embryos, particularly aneuploidy, are a primary cause of implantation failure and miscarriage.
Comprehensive chromosome screening (CCS) aims to identify euploid embryos for transfer, potentially improving success rates.

Purpose of the Study:

To evaluate the clinical utility of CCS employing array comparative genomic hybridization (aCGH).
To assess CCS effectiveness across various patient indications, including recurrent miscarriage, implantation failure, severe male factor, previous trisomy, and advanced maternal age.
To determine the impact of oocyte and embryo origin (fresh vs. vitrified) on CCS outcomes.

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Main Methods:

A retrospective analysis of 1420 CCS cycles utilizing aCGH for embryo analysis.
Day-3 embryo biopsy followed by aCGH, with subsequent day-5 embryo transfer.
Data collected on implantation rates, pregnancy rates, and delivery rates per cycle and per transfer.

Main Results:

Consistent implantation (40.5-54.2%) and pregnancy rates (46.0-62.9%) were observed across all patient groups and oocyte/embryo origins.
Women over 40 experienced lower delivery rates (18.1%) due to a high prevalence of aneuploid embryos (85.3%).
The availability of euploid embryos for transfer was reduced in older women (40.3%).

Conclusions:

CCS using aCGH demonstrates consistent implantation and pregnancy rates across diverse indications.
Aneuploidy remains a critical factor limiting embryo implantation and successful pregnancy, especially in advanced maternal age cases.
CCS is a valuable tool for identifying euploid embryos, but age-related aneuploidy presents a significant challenge to achieving higher delivery rates.