Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Evaluation of Economic Methods to Assess the Social Value of Medical Interventions for Ultra-Rare Disorders (URDS).

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2016

Same author

Exploring attitudes and knowledge of climate change and sustainability in a dental practice: A feasibility study into resource management.

British dental journal·2016

Same author

What's in a bin: A case study of dental clinical waste composition and potential greenhouse gas emission savings.

British dental journal·2016

Same author

The Effectiveness of Group-based Self-management Programmes to Improve Physical and Psychological Outcomes in Patients with Cancer: a Systematic Review and Meta-analysis of Randomised Controlled Trials.

Clinical oncology (Royal College of Radiologists (Great Britain))·2015

Same author

Can a sustainability and health scenario provide a realistic challenge to student nurses and provoke changes in practice? An evaluation of a training intervention.

Nursing & health sciences·2015

Same author

State-dependent cooperation in burying beetles: parents adjust their contribution towards care based on both their own and their partner's size.

Journal of evolutionary biology·2015

Search research articles

Related Experiment Video

Updated: Apr 28, 2026

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Published on: April 12, 2024

Retinal hamartoma in childhood.

A J Dark, J Richardson, J W Howe

Journal of Pediatric Ophthalmology and Strabismus

|June 1, 2014

Summary

This study describes pigment-containing posterior pole lesions in children. Inflammatory signs suggest reactive pathogenesis, with angiography and electro-oculography aiding diagnosis.

Area of Science:

Ophthalmology
Pediatric Ophthalmology
Pathology

Background:

Pigment-containing tumefactions of the posterior pole are rare pediatric ocular conditions.
Understanding their pathogenesis is crucial for accurate diagnosis and management.

Observation:

Two pediatric cases with pigment-containing posterior pole lesions were analyzed.
Clinical presentation included tumefactions that, while provisionally considered hamartomatous, exhibited inflammatory signs.

Findings:

The observed inflammatory signs suggest a potential reactive inflammatory pathogenesis for these lesions.
While many diagnostic tests were non-contributory, fluorescence angiography and electro-oculography proved valuable for differential diagnosis.
Fluorescence angiography revealed dynamic changes in vascular leakage patterns within the mass over a one-year period.

More Related Videos

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Published on: January 22, 2018

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Published on: August 4, 2011

Related Experiment Videos

Last Updated: Apr 28, 2026

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Published on: April 12, 2024

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Published on: January 22, 2018

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Published on: August 4, 2011

Implications:

This highlights the importance of considering reactive inflammatory processes in the differential diagnosis of posterior pole tumefactions.
Advanced imaging techniques like fluorescence angiography are essential for characterizing these lesions and monitoring their progression.
Further research into the inflammatory component of these lesions could lead to improved diagnostic and therapeutic strategies in pediatric ophthalmology.