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Related Experiment Video

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A proposed model membrane and test method for microneedle insertion studies.

Eneko Larrañeta1, Jessica Moore1, Eva M Vicente-Pérez1

  • 1Queens University, Belfast School of Pharmacy, 97 Lisburn Road, Belfast BT9 7BL, United Kingdom.

International Journal of Pharmaceutics
|June 1, 2014
PubMed
Summary
This summary is machine-generated.

Parafilm M(®) is a viable model membrane for microneedle (MN) insertion studies, showing comparable results to biological skin. This offers a rapid, cost-effective method for MN quality control and formulation comparison.

Keywords:
Insertion testsMicroneedlesOptical coherence tomographyPolymeric films

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Medical Device Testing

Background:

  • Microneedle (MN) insertion studies require reliable model membranes for efficient testing.
  • Evaluating MN insertion into biological tissues can be complex and costly.
  • Parafilm M(®) (PF), a blend of hydrocarbon wax and polyolefin, is explored as a potential alternative.

Purpose of the Study:

  • To evaluate Parafilm M(®) as a model membrane for microneedle insertion studies.
  • To compare MN insertion depths into Parafilm M(®) and excised neonatal porcine skin.
  • To assess the utility of Parafilm M(®) for rapid MN quality control and formulation comparison.

Main Methods:

  • Polymeric MN arrays were inserted into Parafilm M(®) and excised neonatal porcine skin.
  • Parafilm M(®) was folded to mimic skin thickness.
  • Insertion depths were measured using optical coherence tomography (OCT) and light microscopy.
  • Forces were applied using a Texture Analyser and by human volunteers.

Main Results:

  • MN insertion depths in Parafilm M(®) were slightly lower than in skin, with differences less than 10% of needle length.
  • Light microscopy provided a rapid, simple method for evaluating insertion depths.
  • Parafilm M(®) insertion depths correlated well with skin, especially under standardized force/time profiles.

Conclusions:

  • Parafilm M(®) serves as a suitable and cost-effective model membrane for microneedle insertion studies.
  • This model membrane facilitates rapid quality control and comparative testing of microneedle formulations.
  • The use of Parafilm M(®) can streamline microneedle research and development processes.