Interplay between RAS and opioids: opening the Pandora of complexities
Anjana Bali1, Puneet Kaur Randhawa1, Amteshwar Singh Jaggi1
1Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India.
Neuropeptides
|June 1, 2014
Summary
The renin-angiotensin system (RAS) and endogenous opioids exhibit complex, bidirectional interactions in the brain and periphery. These neuropeptide systems can positively or negatively influence each other
Area of Science:
- Neurobiology
- Endocrinology
- Pharmacology
Background:
- Angiotensin and endogenous opioids are key neuropeptides with widespread distribution and diverse biological activities.
- The endogenous opioid system comprises enkephalins, dynorphins, and endorphins acting on delta, kappa, and mu receptors.
- Significant positive and negative interactions between the renin-angiotensin system (RAS) and endogenous opioids have been documented.
Purpose of the Study:
- To review the intricate positive and negative interactions between the RAS and endogenous opioid systems.
- To explore the potential mechanisms underlying these complex interplays in both central and peripheral systems.
Main Methods:
- Literature review of existing research on RAS and opioid interactions.
- Analysis of studies investigating the interplay between angiotensin II and opioid peptides.
- Examination of evidence regarding the effects of ACE inhibitors on opioid activity.
Main Results:
- Evidence suggests both synergistic and antagonistic relationships between RAS and opioid systems.
- Angiotensin II may mediate some of its effects via endogenous opioids, and opioids can modulate RAS components.
- Conversely, Ang II can act as an anti-opioid peptide, and opioids may decrease angiotensin release.
Conclusions:
- The interaction between RAS and endogenous opioids is complex, involving both facilitatory and inhibitory mechanisms.
- Understanding these interactions is crucial for elucidating neurobiological processes and potential therapeutic strategies.
- Co-administration of ACE inhibitors with opioids can lead to significant potentiation of opioid effects due to altered opioid metabolism.
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