Anomalous dynamics of DNA hairpin folding

By means of computer simulations of a coarse-grained DNA model we show that the DNA hairpin zippering dynamics is anomalous; i.e., the characteristic time τ scales nonlinearly with N, the hairpin length, τ ∼ N(α) with α>1. This is in sharp contrast to the prediction of the zipper model for which τ ∼ N. We show that the anomalous dynamics originates from an increase in the friction during zippering due to the tension built in the closing strands. From a simple polymer model we get α = 1+ν ≈ 1.59 with ν being the Flory exponent, a result which is in agreement with the simulations. We discuss transition path times data where such effects should be detected.