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Citrucel (methylcellulose/bulk-forming laxative).

M L Swartz

    Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates
    |January 1, 1989
    PubMed
    Summary
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    Patient compliance with bulk laxatives for chronic constipation is poor due to taste and texture. Methylcellulose (Citrucel) offers improved palatability and solubility, potentially enhancing patient adherence and offering cholesterol-lowering benefits.

    Area of Science:

    • Gastroenterology
    • Pharmacology

    Background:

    • Chronic constipation is a common condition often managed with bulk laxatives.
    • Patient non-compliance with bulk laxatives, such as psyllium, is frequently linked to undesirable sensory properties like taste and grittiness.

    Purpose of the Study:

    • To evaluate methylcellulose (Citrucel) as an alternative bulk laxative.
    • To assess the potential for improved patient compliance with methylcellulose due to its palatability and solubility.
    • To explore potential secondary benefits of methylcellulose, such as effects on serum cholesterol.

    Main Methods:

    • Comparative analysis of bulk laxative properties.
    • Assessment of patient-reported outcomes related to palatability and compliance.
    • Review of existing literature on methylcellulose and its physiological effects.

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    Main Results:

    • Methylcellulose (Citrucel) is fully soluble, addressing the grittiness associated with psyllium.
    • Improved palatability of methylcellulose may lead to better patient compliance.
    • Methylcellulose may offer additional benefits, including a potential reduction in serum cholesterol levels.

    Conclusions:

    • Methylcellulose represents a palatable and soluble alternative for managing chronic constipation.
    • Enhanced patient compliance is anticipated with methylcellulose, improving therapeutic outcomes.
    • Further research into the cholesterol-lowering effects of methylcellulose is warranted.