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Updated: Apr 28, 2026

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
Published on: February 17, 2023
Canine stage 1 periodontal disease: a latent pathology
A Whyte1, C Bonastre1, L V Monteagudo2
1Department of Animal Pathology, Faculty of Veterinary Sciences, Universidad de Zaragoza, Miguel Servet, 177, 50.013 Zaragoza, Spain.
Abstract:
To evaluate the potential health issues associated with periodontal disease (PD) in dogs, 1004 teeth from 25 dogs were examined. The dogs were randomly selected, aged 2-14 years, and had at least 95% of their teeth at the first PD stage. Significant positive correlations between plaque grade (PG) and gum inflammation, gingival regression, periodontal pocket, age and serum alanine aminotransferase (ALT) activity were identified. In contrast, PG was negatively correlated to total platelet count. Altogether, these findings suggest that prevention and therapy at the first PD stages can have an important impact on the general health condition of dogs.
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