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Updated: Apr 28, 2026

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization
Published on: June 7, 2016
The importance of microRNAs in the stroma-breast cancer cell interplay
Sergiu Susman1, Ciprian Tomuleasa2, Zsolt Fekete3
1Departement of Morphological Sciences, University of Medicine and Pharmacy "Prof. Dr. Ion Chiricuta", Cluj Napoca, Romania The Research Center for Functional Genomics, Biomedicine and Translational Medicine, Cluj Napoca, Romania.
Abstract:
Breast cancer is one of the most diagnosed cancers in women. Despite outstanding progress over the past few years, breast cancer remains the second leading cause of cancer-related death among women. This fact emphasizes the need for improved diagnostic and prognostic markers, as well as improved understanding of cancer environment, including the crosstalk between epithelial and stromal cells. The tumor microenvironment is paramount in breast cancer progression and dissemination. Accumulating evidence indicates that epigenetic phenomena such as microRNAs are extremely important in cancer homeostasis. Through the improved understanding of the molecular mechanisms involved in the microenvironment-mediated promotion of cancer growth and metastasis, novel targets for therapeutic intervention or early diagnosis may be identified.
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