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Related Experiment Video

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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
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Management of Unplanned Excision for Soft-Tissue Sarcoma With Preoperative Radiotherapy Followed by Definitive

Daniel A Jones1, Charles Shideman, Jianling Yuan

  • 1Departments of *Radiation Oncology †Laboratory Medicine and Pathology §Orthopedic Surgery, University of Minnesota Affiliated Hospitals ∥Biostatistics and Bioinformatics Core, Masonic Cancer Center, University of Minnesota ‡Department of Laboratory Medicine and Pathology, Veterans Administration Medical Center, Minneapolis, MN.

American Journal of Clinical Oncology
|June 1, 2014
PubMed
Summary

Preoperative radiotherapy and surgery offer excellent local control (95%) for patients with inadvertently resected soft-tissue sarcoma. This approach is reasonable, with complications mainly affecting lower extremity sarcomas.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Radiation Oncology

Background:

  • Unplanned excision is common for soft-tissue sarcoma, but optimal management remains unclear.
  • This study addresses outcomes for patients undergoing radiotherapy and surgery after initial inadvertent excision.

Purpose of the Study:

  • To review outcomes of preoperative radiotherapy and definitive surgery for sarcoma patients with prior inadvertent excision.
  • To evaluate the efficacy and safety of this combined treatment approach.

Main Methods:

  • Retrospective review of 44 consecutive soft-tissue sarcoma patients treated between 2004-2012.
  • All patients received preoperative external-beam radiotherapy followed by oncologic surgery.

Main Results:

  • Median follow-up was 36 months.
  • Excellent 5-year local control (95%), recurrence-free survival (86%), and overall survival (94%) were observed.
  • Perioperative morbidity occurred in 25% of patients, primarily in those with lower extremity sarcomas.

Conclusions:

  • Preoperative radiotherapy and surgery represent a viable management strategy for inadvertently resected soft-tissue sarcoma.
  • The approach demonstrates high local control rates.
  • Lower extremity sarcomas are associated with increased perioperative complications.