Related Experiment Video
Updated: Apr 28, 2026

13:50
Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients
Published on: June 11, 2011
11.7K
Rheumatic manifestations in brazilian patients with AIDS
Acta Reumatologica Portuguesa
|June 1, 2014
Summary
Rheumatic complaints like arthralgia are common in patients with acquired immunodeficiency syndrome (AIDS). Antinuclear antibody (ANA) presence in AIDS patients correlates with older age and higher viral load.
Area of Science:
- Rheumatology
- Immunology
- Infectious Diseases
Background:
- Patients with acquired immunodeficiency syndrome (AIDS) frequently experience rheumatic symptoms, including arthritis, arthralgia, dry eyes, and back pain.
- Autoantibodies such as antinuclear antibody (ANA) and rheumatoid factor (RF) can be detected in individuals with AIDS.
Purpose of the Study:
- To determine the prevalence of rheumatic complaints in patients diagnosed with AIDS.
- To investigate the correlation between these rheumatic symptoms and the presence of ANA and RF in AIDS patients.
Main Methods:
- A cohort of 69 AIDS patients (mean age 40.8 years) were assessed for rheumatic complaints, ANA, ENA-6, and RF.
- Demographic data, CD4+/CD8+ cell counts, and viral load were collected for correlation analysis.
Main Results:
- Arthralgia was the most frequent complaint (39.1%), followed by sicca symptoms (21.7%) and inflammatory lumbar pain (13.4%).
- Antinuclear antibody (ANA) was detected in 8.6% of patients and rheumatoid factor (RF) in 10.1%.
- ANA prevalence was significantly higher in older patients and those with elevated viral loads (p=0.03 and p=0.006, respectively).
Conclusions:
- Arthralgia is the predominant rheumatic manifestation in this AIDS cohort.
- The presence of ANA in AIDS patients is associated with advanced age and higher viral load, suggesting a potential link to disease progression.
More Related Videos
Related Concept Videos
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
1.3K
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
1.3K
Rheumatic Heart Disease I: Introduction
1.0K
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
1.0K
Rheumatic Heart Disease III: Medical Management
539
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
539
Rheumatic Heart Disease IV: Nursing Management
484
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
484
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations
25
Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet...
25
Asthma III: Clinical Manifestations
39
Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
39

