Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Olfaction01:25

Olfaction

40.4K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
40.4K
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

10.4K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
10.4K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

13.1K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
13.1K
Depression: Overview01:18

Depression: Overview

1.2K
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
1.2K
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

883
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
883
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

8.8K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
8.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel composite model of PTSD induced by social bullying: validation via multidimensional behavioral and molecular biomarkers.

Molecular psychiatry·2026
Same author

Accelerated continuous theta burst stimulation targeting left primary motor cortex for children with autism spectrum disorder: multicentre randomised sham controlled trial.

BMJ (Clinical research ed.)·2026
Same author

Bed nucleus of the stria terminalis-nucleus accumbens stimulation for depression: A randomized, double-blind, crossover trial.

Cell reports. Medicine·2026
Same author

Bed nucleus of the stria terminalis-nucleus accumbens stimulation for depression: A randomized, double-blind, crossover trial.

Cell reports. Medicine·2026
Same author

Circuit and molecular mechanisms underlying incubation of methamphetamine craving in the prelimbic cortex.

Neuron·2026
Same author

Bilateral sequential accelerated theta-burst stimulation for treatment-resistant depression: an open-label randomized controlled trial.

BMC medicine·2026

Related Experiment Video

Updated: Apr 28, 2026

An Olfactory Preference Test for Measuring Olfactory Hedonic Biases in Mouse Models of Depression
06:27

An Olfactory Preference Test for Measuring Olfactory Hedonic Biases in Mouse Models of Depression

Published on: July 11, 2025

1.2K

Roles of olfactory system dysfunction in depression.

Ti-Fei Yuan1, Burton M Slotnick2

  • 1School of Psychology, Nanjing Normal University, China.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|June 1, 2014
PubMed
Summary
This summary is machine-generated.

The olfactory system plays a role in emotions and memory. Olfactory dysfunction is linked to depression, suggesting potential new treatments through brain stimulation and nasal drug delivery for this mood disorder.

Keywords:
AntidepressantDepressionLimbic systemNeurogenesisOlfactory bulbectomy

More Related Videos

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
08:33

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

9.0K
A Free-breathing fMRI Method to Study Human Olfactory Function
10:42

A Free-breathing fMRI Method to Study Human Olfactory Function

Published on: July 30, 2017

9.0K

Related Experiment Videos

Last Updated: Apr 28, 2026

An Olfactory Preference Test for Measuring Olfactory Hedonic Biases in Mouse Models of Depression
06:27

An Olfactory Preference Test for Measuring Olfactory Hedonic Biases in Mouse Models of Depression

Published on: July 11, 2025

1.2K
Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
08:33

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

9.0K
A Free-breathing fMRI Method to Study Human Olfactory Function
10:42

A Free-breathing fMRI Method to Study Human Olfactory Function

Published on: July 30, 2017

9.0K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Sensory Systems

Background:

  • The olfactory system is integral to sensory perception, emotional regulation, and memory.
  • Olfactory bulbectomy in rats is a long-standing animal model for depression research.
  • Impaired olfaction is observed in chronic stress models and in patients with clinical depression.

Purpose of the Study:

  • To explore the neurobiological links between olfactory system dysfunction and depression.
  • To investigate the potential of novel therapeutic strategies for depression management targeting the olfactory system.

Main Methods:

  • Review of existing literature on the olfactory system and depression.
  • Analysis of animal models (olfactory bulbectomy) and clinical observations in depressed patients.
  • Consideration of emerging therapeutic modalities like brain stimulation and nasal drug delivery.

Main Results:

  • Evidence suggests a significant correlation between olfactory system dysfunction and depressive states.
  • Olfactory impairment is a common feature in both animal models and human patients with depression.
  • The neurobiological underpinnings of depression may involve the olfactory pathways.

Conclusions:

  • Dysfunction in the olfactory system is implicated in the neurobiology of depression.
  • Brain stimulation and nasal drug delivery represent promising avenues for novel depression therapies.