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Related Concept Videos

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Related Experiment Video

Updated: Apr 28, 2026

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
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Reconceiving autoimmunity: An overview.

Alfred I Tauber1

  • 1Cohn Institute for the History and Philosophy of Science and Ideas, Tel Aviv University, Tel Aviv, Israel.

Journal of Theoretical Biology
|June 1, 2014
PubMed
Summary
This summary is machine-generated.

The immune system does not distinguish self from non-self but rather recognizes patterns. All immunity is fundamentally autoimmunity, with disease arising from dysregulation, not a flawed self/non-self model.

Keywords:
AutoimmunityConcinnityEcologySelfSymbiosis

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Area of Science:

  • Immunology
  • Cellular Biology
  • Physiology

Background:

  • The traditional self/non-self model of immunity is a useful but incomplete framework.
  • Immune responses are dynamic and context-dependent, challenging strict demarcation.
  • Host-environment interactions blur the lines between self and foreign entities.

Purpose of the Study:

  • To propose a new conceptual model for understanding immune system function.
  • To re-evaluate the concept of 'autoimmunity' and its implications.
  • To introduce a revised nomenclature for immune system physiology.

Main Methods:

  • Conceptual analysis of existing immunological theories.
  • Reinterpretation of immune system responses within a broader physiological context.
  • Critique of the self/non-self paradigm.

Main Results:

  • The immune system does not possess an inherent 'self' but rather recognizes patterns of reactivity.
  • Immune responses exist on a spectrum, not a binary self/non-self division.
  • Pathological 'autoimmune' conditions are viewed as a degree of dysregulation within this spectrum.

Conclusions:

  • The concept of 'autoimmunity' as distinct from normal immune function is a semantic artifact.
  • A new term, 'concinnity,' is proposed to describe the immune system's role in maintaining organismic identity and integrity.
  • This revised framework offers a more accurate representation of immune system physiology and its homeostatic functions.